Oroxcell propose standardized methods to measure different parameters of ADME, Absorption, Distribution, Metabolism and Elimination.
Percutaneous and intestinal absorption
- Intestinal absorption
- Permeability across in vitro epithelial monolayers
- Ussing chambers
- In situ intestinal perfusion (intestinal segment
of
the
rat
perfused
in
situ)
- Percutaneous absorption
- Reconstituted human epidermis : Episkin™ model (reconstructed from adult human keratinocytes with a functional horny layer,stratum corneum)
- Human excised skin (fresh or frozen skin from human or animal mounted in a Franz cell)
- Read more : Cellular Absorption (PDF)
Hepatic & Extra-hepatic Metabolism
Metabolism
- Metabolic clearance
- Metabolic profile determination
CYP based drug-drug interactions
- In vitro CYP inhibition
- Enzyme mapping
- In vitro CYP induction
- Ex vivo CYP induction
Extra-hepatic metabolism
- Stability in gastrointestinal contents derived from healthy volunteers
- Plasma stability
- Skin metabolism
- Read more Hepatic and extra-hepatic metabolism (PDF)
