Bioanalysis and analytical chemistry
LC-MS/MS:
Triple quadrupole (Applied Biosystems): 1 APl-3200 and 3 API-4000
LC-UV-MS/MS-Radiodetector:
Triple quadrupole (Waters): 1 Quattro Micro coupled with:
- diode array UV detection (Waters 996 DAD)
- radioactive detection (Packard Flo One)
LC-UV-MS:
Single quadrupole (Waters). 1 ZMD coupled with:
- diode array UV detection (Agilent 1100 DA)
HPLC:
4 Alliance HPLC Systems (Waters)
- Diode array UV/visible detectors (Waters)
- Flo One Radiodetector (Packard)
- Qualified Empower system (Waters)
- Method Validation Manager
UPLC:
1 Acquity UPLC System (Waters)
- Diode array UV/visible detector (Waters)
- Qualified Empower system (Waters)
Solid Phase Extraction (SPE):
1 TomTec Quadra-96 workstation
Radioactivity - liquid scintillation:
1 Tri-Carb 2100 TR (Packard)
1 TopCount NXT (Packard)
Fluorescence/Absorbance/Luminescence:
2 Fluostar Optima BMG microplate readers
Physicochemistry and stability
GlpKa-DPAS (Sirius Analytical):
pKa measurement
DSC (Differential Scanning Calorimetry) (TA Instruments):
Melting point measurement
Polymorphism study
3 climatic chambers and 4 ovens (Memmert):
API and drug product forced degradation studies
ICH stability
Formulation characterization
Nanosizer and Coulter Sizer 3 (Malvern – Beckman) :
Droplet or solid particle size measurement
Optical microscope (Leica – Olympus):
Particle shape studies
Dissolution bath (Distek – Sotax):
Dissolution profiling
