Pharmacokinetic studies using laboratory models
Administration
- Mice, rats, hamsters, mini-pigs, dogs
- Intravenous, subcutaneous, oral, intraperitoneal, intramuscular, intradermic and intrarectal routes
- Possibility of administrating radiolabeled compounds
Sampling
- Blood: exposure and response time course
- Tissues/organs: for histology analysis or determination of CYP450 activity
Dosing
- Bioanalysis and data treatment
- Determination of PK parameters (WinNonlin®)
Pharmacokinetic studies in human healthy volunteers
- Gastro-intestinal perfusion under fed or fasted conditions with intestinal and blood sampling
- Phase I PK studies
Support for toxicological studies
- Toxicokinetic studies
- Repeated dose
Support for induction / inhibition studies
- Determination of CYP450 activity
Mass Balance
Surgery applications
Catheterisation in rat
- Jugular vein
- Femoral vein
- Mesenteric vein
In-situ intestinal perfusion
- Pre-systemic and systemic blood sampling
- Gastro-intestinal sampling
Ussing chambers
Read more on Pharmacokinetic studies (PDF)
