Caco-2 / TC7 cells

Products

"Reliable, ready-to-use, and controlled intestinal absorption in vitro model”Oroxcell makes available the most relevant Caco-2 cells clone.YOU ORDERWE DELIVER mature, ready to use, Caco-2/TC7 cells on Transwell inserts.Since 2004, we used this specific Caco-2 cells clone to tests over 3 000 pharmaceuticals, and our model is continuously qualified with reference molecules, to ensure quality and reproducibility.

Ready to use Caco-2 / TC7 plated cells

Presentation

Oroxcell sells Ready to use plated cells, which are granted from a public scientific and technological institute: INSERM. They are used for numerous research regarding intestinal absorption.
The Caco-2 / TC7 cells are used from Screening to Preclinical Developments.
Caco-2 / TC7-cell plates as ready to use plated cells in 24 and 96 wells plates.​
License granted from INSERM
100 % customer satisfaction (Pharma and Nutrition Health)

Uses

Caco-2 cell line is used in in vitro models to study intestinal absorption and also for preclinical research such as:
Intestinal Pharmacology
Intestinal Absorption, including BCS Biowaiver studies:  The BCS is well established as a valid approach for waiving the requirements for in vivo BA and BE studies of Class I and Class III drugs and is used to support dossiers of novel oral drug products and generic drug development.
Toxicology of the Intestine
Caco-2 / TC7 cell clone was isolated from a late passage of the parental Caco-2 line and has shown to consist of a more homogeneous population with respect to the most representative functions of the small intestinal enterocytes with more developed intercellular junctions. "Caco-2 / TC7 cell line characterization for intestinal absorption : 

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References

Some publications using Caco-2 / TC7 cells

Caro et al., Characterization of a newly isolated Caco-2 clone (TC7), as a model of transport processes and biotransformation of drugs; International Journal of Pharmaceutics 116 (1995) 147 – 158
Zucco et al., An interlaboratory study to evaluate the effects of medium composition on the differentiation and barrier function of Caco-2 cell line; ATLA 33, 603-618, 2005
Obringer et al., Suitability of the in vitro Caco-2 assay to predict the oral absorption of aromatic amine hair dyes, Toxicol In Vitro, 2016 Apr; 32:1-7.
Van de Walle et al., Inflammatory parameters in Caco-2 cells: effect of stimuli nature, concentration, combination and cell differentiation, Toxicol In Vitro. 2010 ; 24(5):1441-9.
Roberta Misasi et al., Modulatory Effect of Gliadin Peptide 10-mer on Epithelial Intestinal CACO-2 Cell Inflammatory Response. PLoS One. 2013 Jun 18;8(6)
Elena Mengheri et al., Lactobacillus amylovorus Inhibits the TLR4 Inflammatory Signaling Triggered by Enterotoxigenic Escherichia coli via Modulation of the Negative Regulators and Involvement of TLR2 in Intestinal Caco-2 Cells and Pig Explants, PLoS One. 2014; 9(4): e94891 ; doi: 10.1371/journal.pone.0094891